Technical Program

Paper Detail

Paper:	SA-AM-SS1.6
Session:	Towards Vertical Integration of Biomedical Data
Time:	Saturday, April 8, 11:30 - 11:50
Presentation:	Special Session Oral
Title:	The Epitheliome Project: Multiscale Agent-Based Modeling of Epithelial Cells
Authors:	Rod Smallwood; University of Sheffield
	Mike Holcombe; University of Sheffield
Abstract:	The aim of the Epitheliome Project is to develop a computational model of cell behaviour within the context of tissue architecture, differentiation, wound repair and malignancy. Integration is central to tissue development - for skin, integration between mesenchymal and epithelial tissue; at the physical level from focal adhesions and adherens junctions to cytoskeleton to whole tissue; at the signalling level from control of gene expression through to development of gradients controlling histodifferentiation; and integration in the sense of the development of tissues as an emergent property of cell behaviour. An individual-based model of the cell is used, and tissue development is thus a result of the interaction of individual cells. The limit of a large number of individual cells is a continuum model of tissue, and individual cells can contain continuum or differential equation models of cellular mechanisms. The hierarchical modeling paradigm is described.

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