TUT-1: Biomedical Optical Imaging

Date: Thursday, April 12
08:00 - 12:30

Presented by

Charles Bouman, Purdue University

1. Fluorescence Imaging and Spectroscopy
   • Define NIR optical imaging, endoscopic and deep tissue applications
     • Scattering, angular and angle integrated
     • Absorption
   • Polarization in NIR optical techniques, for endoscopy and deep tissue
   • Molecular imaging with fluorescence optical techniques
     • Fluorescence decay process
     • Excitation/Emission processes
     • FLIM
   • Fluorescence spectroscopies
   • Fluorescent contrast agents - chemistry
   • Feed-back session
2. Forward Models for Diffuse Optical Tomography and Fluorescence Tomography
   • Methods, Instrumentation, Governing equations
     • CW
     • Time-domain
     • Frequency-domain
   • Forward Modeling for Deep Tissue Imaging
     • Transport equation and diffusion equation for ODT
     • Coupled diffusion equation for fluorescence ODT
     • Frequency-domain and time domain models
   • Feed-back session
3. Inverse Methods for Diffuse Optical Tomography and Fluorescence Tomography
   • Approaches
     • Direct methods
     • Bayesian methods
     • optimization approaches
   • Gradient computations
     • Frechet derivatives
     • Adjoint differentiation
     • Computational complexity
   • Optimization techniques
     • Gauss-Seidel, Jacobi, CG
     • Multigrid algorithms
     • Convergence properties
   • Adaptive parameter estimation (source/detector calibration)
   • Inversion of fluorescence problem
   • Evaluation of measurement geometry
   • Kenetic modeling
   • Feed-back session
4. Clinical Applications of Optical Imaging
   • Small animal applications of optical imaging
   • Process of FDA approval(human) and validation (animal)
   • Image quality assessment
   • Remaining Frontiers
   • Feedback session

Speaker Biography

Charles A. Bouman received a B.S.E.E. degree from the University of Pennsylvania in 1981, and a MS degree in electrical engineering from the University of California at Berkeley in 1982. From 1982 to 1985, he was a staff member in the Analog Device Technology Group at MIT, Lincoln Laboratory. In 1987 and 1989, he received MA and Ph.D. degrees in electrical engineering from Princeton University under the support of an IBM graduate fellowship. In 1989, he joined the faculty of Purdue University where he holds the rank of Professor with a primary appointment in the School of Electrical and Computer Engineering and a secondary appointment in the Department of Biomedical Engineering.

Professor Bouman's research focuses on the use of statistical image models, multiscale techniques, and fast algorithms in applications including tomographic image reconstruction, multiscale image segmentation, image printing and rendering, and document segmentation and compression. Professor Bouman's research has resulted in new methods for image rendering, halftoning, and display that have been widely used in commercial products. Professor Bouman has authored over 50 journal publications, over 150 conference publications, and is an inventor on 10 issued patents. He has performed research for numerous government and industrial organizations including the National Science Foundation, the US Army, Hewlett-Packard, General Electric, Samsung Electronics Corporation, Xerox, NEC Corporation, Apple Computer, and Eastman Kodak.

Professor Bouman is a Fellow of the IEEE, a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), a Fellow of the society for Imaging Science and Technology (IS&T), a member of the SPIE professional society, a recipient of IS&T’s Raymond C. Bowman Award for outstanding contributions to digital imaging education and research, and a University Faculty Scholar of Purdue University. He is currently the Editor-in-Chief Elect for the IEEE Transactions on Image Processing, a member of the IEEE Biomedical Image and Signal Processing Technical Committee, and a member of the Steering Committee for the IEEE Transactions on Medical Imaging. He has been an associate editor for the IEEE Transactions on Image Processing and the IEEE Transactions on Pattern Analysis and Machine Intelligence. He has also been Co-Chair of the 2006 SPIE/IS&T Symposium on Electronic Imaging, Co-Chair of the SPIE/IS&T conferences on Visual Communications and Image Processing 2000 (VCIP), a Vice President of Publications and a member of the Board of Directors for the IS&T Society, and he is the founder and co-chair of the SPIE/IS&T conference on Computational Imaging.