Technical Program

Paper Detail

Paper:	FR-PM-PS3.8
Session:	Image Guided Diagnosis, Surgery and Therapy
Time:	Friday, April 7, 13:30 - 14:50
Presentation:	Poster
Title:	Correlation of Magnetic Resonance Spectroscopic Imaging and Intracranial EEG Localization of Seizures
Authors:	Edward Sharff; Yale University
	Xenophon Papademetris; Yale University
	Hoby Hetherington; Albert Einstein College of Medicine
	J. W. Pan; Albert Einstein College of Medicine
	Hitten Zaveri; Yale University
	Hal Blumenfeld; Yale University
	Robert Duckrow; Yale University
	Susan Spencer; Yale University
	Dennis Spencer; Yale University
	James Duncan; Yale University
	Edward Novotny; Yale University
Abstract:	Two and a half million people in US have epilepsy 600,000 individuals have medically intractable epilepsy. Epilepsy surgery offers an alternative treatment and a potential cure. In certain patients, particulary subjects with normal anatomical MRI, evaluation often includes intracranial electrode recording. Continuous monitoring of electrical signals directly from the brain for periods of 1 to 14 days are performed to record actual seizures that provide more precise localization of seizures. Magnetic resonance spectroscopic imaging (MRSI) offers the potential to localize such regions non-invasively. In this study we present results from a comparison of such abnormal region identification for ten patients from both intracranial electrodes and MRSI. The analysis employed both rigid and non-rigid registration methods, as well as localization of intracranial electrodes from CT images. We found that IcEEG and MRSI localization methods were concordant in all ten subjects.

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