Technical Program

Paper Detail

Paper:	SA-AM-OS1.2
Session:	MRI Acquisition and Reconstruction
Time:	Saturday, April 8, 09:50 - 10:10
Presentation:	Oral
Title:	3-D Tomographic Reconstruction of the Average Propagator from MRI Data
Authors:	Valery Pickalov; Russian Academy of Sciences
	Peter Basser; National Institutes of Health
Abstract:	The measurement of the 3-D 'average propagator', P(r), from diffusion-weighted (DW) NMR or MRI data has been a 'holy grail' in materials science and biomedicine, as P(r) provides detailed microstructural information, particularly about restriction, without assuming an underlying diffusion model. While Callaghan proposed a 3-D Fourier transform relationship between P(r) and the DW signal attenuation, E(q) [1], using it to measure P(r) from E(q) data is not currently feasible biologically or clinically, owing to the staggering amount of DW data required. To address this problem, we propose that computed tomography principles can be applied to reconstruct P(r) from DW signals. Moreover, this reconstruction can be performed efficiently using many fewer DW E(q) data as compared to conventional 3-D q-space MRI [1] or Diffusion Spectrum Imaging (DSI) [2] by employing a priori information about E(q) and P(r).

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